We have a strong interest in role of L-type calcium channels (LTCC) for the regulation of signal communication among retinal neurons. Mutations in the CACNA1F gene encoding Cav1.4 LTCCs were identified among patients diagnosed with incomplete congenital night blindness (OMIM: 30071). Our profound background on physiological and pharmacological LTCC features and the expertise in retinal function and morphology help us to understand how different channel phenotypes result in defective retinal synaptic transmission in the patients.
University of Innsbruck
Institute of Pharmacy, Pharmacology and Toxicology